| Response of nevus of Ota to Q-switched alexandrite laser according to treatment interval |
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| 作者姓名： | 卢忠 陈军庞 王侠生 方丽华 焦圣 黄雯 |
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| 作者单位： | Department of Dermatology，Huashan Hospital，Medical College of Fudan University，Shanghai 200040，Department of Dermatology，Huashan Hospital，Medical College of Fudan University，Shanghai 200040，Department of Dermatology，Huashan Hospital，Medical College of Fudan University，Shanghai 200040，Department of Dermatology，Huashan Hospital，Medical College of Fudan University，Shanghai 200040，Department of Dermatology，Huashan Hospital，Medical College of Fudan University，Shanghai 200040，Department of Dermatology，Huashan Hospital，Medical College of Fudan University，Shanghai 200040 |
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| 基金项目： | This work was supported by the Shanghai Municipal Natural Science under the Grant (97-181). |
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| 摘 要： | In order to determine the appropriate treatment interval, 267 patients who underwent 3 sessions of treatment with Q-switched alexandrite laser were divided into 4 groups according to treatment interval, and their clinical responses were compared. Among them, 187 were asked about the process of pigment fading. Moreover, light and transmission electron microscopy were performed. It was noted that the clinical response of the 5 - 6 month interval group was significantly better than that of the 3 - 4 month group, but showed no significant difference from that of the 7 - 8 or ≥ 9 month group. 80.21% of investigated patients stated that marked pigment fading could no longer be observed 7 months after irradiation. 4 months after irradiation, the degenerated melanosomes and cell debris were still scattered among collagen fibers, scavenged gradually by macrophage. In conclusion, an appropriate treatment interval is 5 - 6 months.
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Response of nevus of Ota to Q-switched alexandrite laser according to treatment interval |
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| Abstract: | In order to determine the appropriate treatment interval, 267 patients who underwent 3 sessions oftreatment with Q-switched alexandrite laser were divided into 4 groups according to treatment interval,and their clinical responses were compared. Among them, 187 were asked about the process of pigmentfading. Moreover, light and transmission electron microscopy were performed. It was noted that theclinical response of the 5 - 6 month interval group was significantly better than that of the 3 - 4 monthgroup, but showed no significant difference from that of the 7 - 8 or ≥ 9 month group. 80.21% ofinvestigated patients stated that marked pigment fading could no longer be observed 7 months afterirradiation. 4 months after irradiation, the degenerated melanosomes and cell debris were still scatteredamong collagen fibers, scavenged gradually by macrophage. In conclusion, an appropriate treatmentinterval is 5 - 6 months. |
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