氟哌酸1HNMR的测定及过渡金属离子对其影响

氟哌酸^*即1-乙基-6-氟-4-氧-7-(1-哌嗪)-3-(1,4-二氢化喹啉甲酸]是一种广谱、安全、有效、可供口服的抗感染药。我们测定了它的¹H自旋-晶格弛豫时间T₁及其在Cr³⁺、Mn²⁺、和Fe³⁺等过渡金属离子存在下的T₁值。实验结果表明,在加入过渡金属离子前后,氟哌酸不同位¹H的T₁值发生了一定的变化。据此可揭示过渡金属离子和氟哌酸形成配合物的配位点,从而可确定所形成配合物的结构。

T_1 OF THE NORFLOXACIN AND THE EFFECTS OF TRANSITION METAL IONS

The norfloxacin is an effective and safe anti-infective with broad-spectrum, and can be taken orally ·Its ¹H spin-lattice relaxation times (T₁) were determined in the presence and absnce of some transintion metal ions such as Cr³⁺, Mn²⁺ and Fe³⁺.The experimental results showed that T₁ values appeared to vary regularly by the addition of these paramagnetic metal ions with unpaired electrons in the high spin state. The T₁ values of ¹H at different sites reduced variously m-ong which the T₁ values of 2-H and 5-H reduced most obviously. The structures of the complexes, bonded states and bonding quantity are discussed with respect to the relaxation times thus measured.