| 2,4-二氨基-6-(取代苄基)-5-甲基吡啶(2,3d)并嘧啶类化合物的13C NMR研究 |
| |
| 引用本文： | 封春梅,张怡.2,4-二氨基-6-(取代苄基)-5-甲基吡啶(2,3d)并嘧啶类化合物的13C NMR研究[J].波谱学杂志,1993,10(2):177-184. |
| |
| 作者姓名： | 封春梅 张怡 |
| |
| 作者单位： | 1. 北京医科大学波谱分析室, 北京 100083;2. 北京医科大学药化教研室 |
| |
| 摘 要： | 2,4-二氨基-6-(取代苄基)-5-甲基吡啶(2,3d)并嘧啶类化合物是一类很有前途的抗癌新药。本文研究了24种7位氯代和氧代的该类化合物的碳谱,归属了母核及取代苄基上各碳的化学位移,并对两种取代对母核碳上的化学位移的影响规律进行了探讨,文中所有数据迄今未见文献报道。
|
| 关 键 词： | 13C NMR 2 4-二氨基-6-(取代苄基)-5-甲基吡啶(2 3d)并嘧啶 |
| 收稿时间： | 1992-03-20 |
13C NMR STUDY ON 2,4-DIAMINO-5-METHYL-6-SUBSTITUTED-BENZYL PYRIDO-(2,3d) PYRIMIDINES |
| |
| Feng Chunmei,Qiao Liang,Gao Congyuan,Zhang Yi,Li Renli.13C NMR STUDY ON 2,4-DIAMINO-5-METHYL-6-SUBSTITUTED-BENZYL PYRIDO-(2,3d) PYRIMIDINES[J].Chinese Journal of Magnetic Resonance,1993,10(2):177-184. |
| |
| Authors: | Feng Chunmei Qiao Liang Gao Congyuan Zhang Yi Li Renli |
| |
| Institution: | Beijing Medical University, Beijing 100083 |
| |
| Abstract: | 2,4-diamino-5-methyl-6-substituted-benzyl pyrido-(2,3d) pyrimidines are a kind of promising anticancer drugs. 13C NMR spectra of 24 kinds of 7-chloro and 7-oxo compounds have been studied in this paper. The chemical shifts of all carbons in the parent nuclei and subitituted benzyl have successfully been assigned. The influential factors on chemical shifts of all carbons in parent nuclei for two substituted groups have been approached in depth. To date, the data in this paper have not been published in the world. |
| |
| Keywords: | 13C NMR 2 4-diamino-5-methyl-6-substituted-benzyl pyrido-(2 3d) pyrimidines |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《波谱学杂志》浏览原始摘要信息 |
| 点击此处可从《波谱学杂志》下载免费的PDF全文 |
|
