| NMR研究β-环糊精对布洛芬的手性识别 |
| |
| 引用本文： | 王恩举,陈光英,彭明生.NMR研究β-环糊精对布洛芬的手性识别[J].波谱学杂志,2009,26(2):216-222. |
| |
| 作者姓名： | 王恩举 陈光英 彭明生 |
| |
| 作者单位： | 海南省热带药用植物化学重点实验室,海南师范大学,化学系,海南,海口,571158;海南省热带药用植物化学重点实验室,海南师范大学,化学系,海南,海口,571158;海南省热带药用植物化学重点实验室,海南师范大学,化学系,海南,海口,571158 |
| |
| 基金项目： | 海南师范大学博士科研启动资助项目 |
| |
| 摘 要： | 用1H NMR和13C NMR研究了β-环糊精对外消旋布洛芬的手性识别. 外消旋布洛芬与β-环糊精形成包合物后，其1H NMR和13C NMR图谱的化学位移和峰形都有所变化，手性碳附近的某些原子所对应的吸收峰裂分为两组信号, 这两组信号分别对应布洛芬的两种対映异构体. 结果显示, 对于布洛芬, β-环糊精是一个方便而有效的手性溶解剂.
|
| 关 键 词： | 核磁共振(NMR) β-环糊精 布洛芬 手性识别 手性溶解剂 |
| 收稿时间： | 2008-11-17 |
| 修稿时间： | 2008-12-16 |
NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes |
| |
| WANG En-ju,CHEN Guang-ying,PENG Ming-sheng.NMR Studies of Chiral Discrimination of Ibuprofen Enantiomers in β-Cyclodextrin Inclusion Complexes[J].Chinese Journal of Magnetic Resonance,2009,26(2):216-222. |
| |
| Authors: | WANG En-ju CHEN Guang-ying PENG Ming-sheng |
| |
| Institution: | (Key Laboratory of Tropical Pharmaceutical Herb Chemistry of Hainan Province, Department of Chemistry, Hainan Normal University, Haikou 571158, China) |
| |
| Abstract: | The chiral recognition of racemic ibuprofen by β-cyclodextrin was studied by 1H and 13C NMR spectroscopy. The 1H and 13C spectra of ibuprofen complexing with β-cyclodextrin were shown to be different from those of free ibuprofen. Some peaks of the atoms adjacent to the chiral carbon atom showed splitting into two parts, corresponding to the two enantiomers of ibuprofen respectively. The result demonstrated that β-cyclodextrin can be used as a convenient and effectual chiral solvating agent. |
| |
| Keywords: | NMR β-cyclodextrin ibuprofen chrial discrimination chiral solvating agent |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《波谱学杂志》浏览原始摘要信息 |
| 点击此处可从《波谱学杂志》下载免费的PDF全文 |
|
