| 地塞米松棕榈酸酯的NMR数据解析 |
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| 引用本文： | 张海艳,吴鸣建,董建军,付经国,陈涛,赵天增.地塞米松棕榈酸酯的NMR数据解析[J].波谱学杂志,2004,21(4):405-411. |
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| 作者姓名： | 张海艳 吴鸣建 董建军 付经国 陈涛 赵天增 |
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| 作者单位： | 1.郑州大学 化学系，河南 郑州 450052；2.河南省生物技术开发中心，河南 郑州 450002; ;
3.河南省科学院 化学研究所，河南 郑州 450002；4.西安力邦企业，陕西 西安 710075 |
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| 摘 要： | 参考地塞米松在D2O中检测的的1H、19F NMR数据、棕榈酸的1H、13C NMR标准图谱数据和Lindeman-Adams经验公式，对地塞米松棕榈酸酯进行了1H和13C MNR检测，通过DEPT和1H-1H COSY、HMQC、HMBC等2D NMR技术对该化合物所有的1H和13C NMR信号进行了全归属和详细解析.
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| 关 键 词： | NMR 归属 2D NMR 地塞米松棕榈酸酯 |
| 文章编号： | 1000-4556(2004)04-0405-07 |
| 收稿时间： | 2004-04-19 |
| 修稿时间： | 2004年4月19日 |
AN NMR STUDY OF DEXAMETHASONE PALMITATE |
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| ZHANG Hai-yan.AN NMR STUDY OF DEXAMETHASONE PALMITATE[J].Chinese Journal of Magnetic Resonance,2004,21(4):405-411. |
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| Authors: | ZHANG Hai-yan |
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| Institution: | 1.Zhengzhou University, Zhengzhou 450052，China;
2.Biotechnology Developing Center of Henan Academy of Science, Zhengzhou 450002, China;
3.Chemistry Institute, Hennan Academy of Science, Zhengzhou 450002,China;
4.Xi'an Libang Corporation, Xi'an 710075, China |
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| Abstract: | Dexamethasone palmitate incorporated into liposomes (liposteroid) was developed as a targeting anti-inflammatory drug (limethason) used mainly for treatment of rheumatoid arthritis. In this study, 1D (~1H, ~(13)C NMR and DEPT) and 2D (~1H-~1HCOSY,HMQC and HMBC) NMR spectra of dexamethasone palmitate in chloroform were obtained, assigned and analyzed. The structure of dexamethasone palmitate in chloroform was elucidated by referring to the ~1H and ~(19)F NMR spectra of dexamethason in the aqueous solution, the standard ~1H and ~(13)C NMR spectra of palmitate and the Lindeman-Adams experimental formula. |
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| Keywords: | NMR 2D NMR |
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