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| 一种新的DENUDATINE型C20二萜生物碱结构的NMR研究 | |
| 引用本文： | 缪振春,冯锐,周永新,李光玉,郝志刚,刘静涵.一种新的DENUDATINE型C20二萜生物碱结构的NMR研究[J].波谱学杂志,1999,16(6):1. |
| 作者姓名： | 缪振春 冯锐 周永新 李光玉 郝志刚 刘静涵 |
| 作者单位： | 1. 军事医学科学院毒物药物研究所 2. 军事医学科学院国家生物医学分析中心,北京,100850 3. 中国药科大学植物化学研究室,南京,210009 |
| 摘 要： | 从内蒙西伯利亚乌头中分离得一个新的C20二萜生物碱，采用选择性远程DEPT，同核和异核二维NMR技术相结合进行了研究，其结构确定为Lepenine的C－11基向立体异构体，定名为11a－hydroxylapenine．结果表明，选择性远程DEPTNMR技术对于连接这类化合物中被季碳和杂原子分割的NMR自旋体系，测定基本骨架和确定信号归属都有独到之处． |
| 关 键 词： | 选择性远程DEPT技术 C20二萜生物碱 结构测定 二维核磁共振 立体化学 |
| 修稿时间： | 1999-07-12 |
NMR STUDIES ON THE STRUCTURE OF A NEW DENUDATINE DITERPENOID-TYPE ALKALOID |
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| MIAO Zhenchun,FENG Rui,ZHOU Yongxin,LI Guangyu,HAO Zhigang,LIU Jinghan.NMR STUDIES ON THE STRUCTURE OF A NEW DENUDATINE DITERPENOID-TYPE ALKALOID[J].Chinese Journal of Magnetic Resonance,1999,16(6):1. | |
| Authors: | MIAO Zhenchun FENG Rui ZHOU Yongxin LI Guangyu HAO Zhigang LIU Jinghan |
| Abstract: | A new C20 diterpenoid alkaloid has been isolated from Aconitum barbatum var.hispidum Ledeb. Its structure has been elucidated as (1) using a combination of the selectivelong-range DEPT, homo-and heteronuclear 2D NMR techniques. The results showed thaiselective long-range DEPT NMR technique is very effective and convenient for the connection of 1H NMR spin systems separated by quaternary carbons and heteroatoms and assignment of NMR spectra of this class of compounds. Compoud (1) is a epimer of the knowncompound lepenine (2) at C-11 and named as 11a-hydroxy lepenine. |
| Keywords: | Selective long-range DEPT C_(20) diterpenoid alkaloid Structural determination NMR |
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