1—(4—吡啶甲酰)—4—芳基氨基硫脲类和3—(4—吡啶基)—4—芳基—1,2,4—三唑啉—5—硫酮类化合物~(13)C—NMR谱研究

本文测定了新合成的,具有生理活性的1-(4-吡啶甲酰)-4 -苯基氨基硫脲,1-(4-吡啶甲酰)-4-对氯苯基氨基硫脲,1-(4 -吡啶甲酰)-4-对溴苯基氨基硫脲3-(4-吡啶基)-4-苯基-1,2,4,-三唑啉-5-硫酮,3-(4-吡啶基)-4-对氯苯基-1,2,4,-三唑啉-5-硫酮,3-(4-吡啶基)-4-对溴苯基-1,2,4-三唑啉-5-硫酮六个新化合物的~(13)C-NMR谱,并通过~(13)C-NMR谱中的宽带去偶,偏共振及APT技术,模型化合物对照,讯号强度对比及芳基取代基常数计算等方法,进行了上述化合物~(13)C-NMR谱峰的归属,并得到了甲酰肼基在吡啶环4位取代后对吡啶环各碳所产生的取代基效应.

STUDY OF ~(13)C-NMR SPECTRA FOR THE COMPOUNDS OF 1-(4-PYRIDINE ACYL) -4-ARYL THIOSEMICARBAZIDE AND 3-(4 - PYRIDINE) - 4 - AROMATIC -1,2,4 - TRIAZOLINE - 5 - THIONE

The carbon-13 NMR spectra of 1 -(4-pyridine acyl) -4-phenyl thioscmicarbazide , 1-(4-pyridine acyl) -4-p-chloro-phenyl thiosemicarbazide, 1-(4-pyridine acyl) -4-p-bromo-phenyl thiosemicarba/ide, 3-(4-pyridinyl) -4-phenyl-1, 2, 4-triazoline-5 -thionc, 3-( 4-pyridinyl) -p-chloro phenyl-1, 2, 4-triazoline- 5 -thione, 3-(4-pyridinyl) -p-bromo phenyl-1 , 2, 4 -triazoline-5 -thione and their derivatives were studied in this paper. The chemical shifts of various carbon resonance peaks were assigned by the proton-noise decoupling, Off-resonance, APT-technique, and use of empirical methods . At the same time, the substituent effects of 4-hydrazide in monosubstituted pyridinc were obtained. These parameters are Z42 (Z46) 0. 1ppm Z43 (Z45) -3. 3ppm and Z44 3. 9ppm (solvent: polysol; reference: TMS).