新型葫芦[6]脲纳米颗粒超极化129Xe"分子笼"研究

在相同浓度下，超极化¹²⁹Xe的核磁共振（NMR）灵敏度是传统质子NMR的10 000倍以上，但单原子Xe不具有靶向性，只有单一NMR信号.若超极化¹²⁹Xe与“分子笼”相结合，就能获得新的“笼”内Xe信号，为发展超极化¹²⁹Xe分子探针奠定基础.因此，构建新型的“分子笼”是发展新型超极化¹²⁹Xe分子探针的一个重要方向.葫芦6]脲纳米颗粒的出现能改善以葫芦6]脲为主体的¹²⁹Xe分子探针水溶性差、信号弱等缺点.本文构建了水溶性的葫芦6]脲纳米颗粒，并发现其具有葫芦6]脲/纳米颗粒内部两个“笼”内¹²⁹Xe信号.这一发现使这种纳米颗粒具有成为超极化¹²⁹Xe分子探针的潜力，能降低检测结果中假阳性和假阴性的发生率，值得更深入的探索和研究.

A Novel Molecular Cage for Hyperpolarized 129Xe Based on Cucurbit[6]uril Nanoparticles

Hyperpolarized ¹²⁹Xe NMR has a detection sensitivity up to 10 000 times higher than that in the conventional ¹H NMR. Hyperpolarized ¹²⁹Xe gas has only one NMR signal, but can produce multiple signals when combined with molecular cages, providing the chances to develop targeted molecular probes. In this paper, water-soluble cucurbit6]uril nanoparticles were used for loading hyperpolarized ¹²⁹Xe gas to construct targeted molecular probes. It was observed that such molecular probes had double "cage" signals and the potential to be developed into multi-functional probes.