| 8-O-4′型异木脂素立体构型的测定方法 |
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| 引用本文： | 原忠,李铣.8-O-4′型异木脂素立体构型的测定方法[J].波谱学杂志,2003,20(3):307-314. |
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| 作者姓名： | 原忠 李铣 |
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| 作者单位： | 沈阳药科大学中药学院28#信箱，辽宁沈阳 110016 |
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| 摘 要： | 综述了关于8-O-4′型异木脂素的立体化学方面的研究. 总结了测定8-O-4′型异木脂素的相对构型和绝对构型的常用方法. 1H NMR谱是研究C-7 和C-8间相对构型的常用方法, 若H-7的偶合常数较小，在2.7～5.0 Hz范围内，为赤式；若H-7的偶合常数较大，在6.0～8.6 Hz范围内，则为苏式. 结合NOE差谱以及CD谱的测定，或者Mosher's法，可进一步阐明其绝对构型.
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| 关 键 词： | 核磁共振 8-O-4′型异木脂素 立体构型 CD谱 NOE差谱 Mosher's法 |
| 文章编号： | 1000-4556(2003)03-0307-08 |
| 收稿时间： | 2003-03-31 |
| 修稿时间： | 2003年3月31日 |
NMR METHODS FOR DETERMINING THE CONFIGURATION OF 8-O-4'NEOLIGNANS |
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| YUAN Zhong,LI Xian.NMR METHODS FOR DETERMINING THE CONFIGURATION OF 8-O-4''''NEOLIGNANS[J].Chinese Journal of Magnetic Resonance,2003,20(3):307-314. |
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| Authors: | YUAN Zhong LI Xian |
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| Institution: | School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, P.O. Box 28#, Shenyang 110016, China |
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| Abstract: | The NMR methods for determining the relative and absolute configurations of 8-O-4′Neolignans were reviewed. The relative stereochemistry between C-7
and C-8 should be in theerythro form if the coupling constant between the measured by 1H NMR is small (J=2.7～5.0 Hz). If the coupling constant me
asured is larger (J=6.0～8.6 Hz), the configuration is in the threo form. With the application of NOE difference spectroscopy, CD assay and Mosher's method, the absolute configuration can be determined. |
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| Keywords: | NMR 8-O-4′Neolignans configuration NOE difference spectroscopy CD spectroscopy Mosher's method |
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