| 用1N-HMR方法测定1-乙基-7-氯-6-氟-1.4-二氢-4-氧喹啉-3-羧酸乙酯与其异构体的相对含量 |
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| 引用本文： | 郭惠元,顾慧儿,张忠岳,孙兰英.用1N-HMR方法测定1-乙基-7-氯-6-氟-1.4-二氢-4-氧喹啉-3-羧酸乙酯与其异构体的相对含量[J].波谱学杂志,1987,4(3):229-231. |
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| 作者姓名： | 郭惠元 顾慧儿 张忠岳 孙兰英 |
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| 作者单位： | 中国医学科学院抗菌素研究所 北京 |
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| 摘 要： | 本文报道用1H-NMR技水,采用峰高和积分两种方法测定了1-乙基-7-氯-6-氟-1.4二氢-4-氧喹啉-3-羧酸乙酯与其异构体的相对含量,并对这两种方法进行了讨论。
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| 收稿时间： | 1986-11-17 |
DETERMINATION OF RELATIVE CONTENTS OF ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1, 4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLATE AND ITS ISOMER BY 1H NMR METHOD |
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| Guo Huiyuan,Gu Huier,Zhang Zhongyue,Sun Lanying.DETERMINATION OF RELATIVE CONTENTS OF ETHYL 7-CHLORO-1-ETHYL-6-FLUORO-1, 4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLATE AND ITS ISOMER BY 1H NMR METHOD[J].Chinese Journal of Magnetic Resonance,1987,4(3):229-231. |
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| Authors: | Guo Huiyuan Gu Huier Zhang Zhongyue Sun Lanying |
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| Institution: | Institute of Antibiotics, Chinese Academy of Medical Sciences, Beijing |
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| Abstract: | In this paper the utilization of 1H NMR including both peak height and integration determination methods is reported in the estimation of the relative contents of ethyl 7-chloro-l-ethyl-6-fluoro-1.4-dihydro-4-oxoquinoline-3-carboxyla-te and its 5-chloro isomer which were produced in the cyclization reaction of di-ethyl 3-chloro-4-fluoroanilinemethylene-malonate in the presence of different Lewis acids. |
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