| 天然孕甾烷-17(20)-烯中C-17位双键构型的快速测定 |
| |
| 引用本文： | 江海鹏,蒋先旺,张许,刘买利.天然孕甾烷-17(20)-烯中C-17位双键构型的快速测定[J].波谱学杂志,2011,28(1):93-98. |
| |
| 作者姓名： | 江海鹏 蒋先旺 张许 刘买利 |
| |
| 作者单位： | 1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center of Magnetic Resonance, (Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences), Wuhan 430071, China;
2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
| |
| 基金项目： | 国家自然科学基金资助项目(20875098); 武汉市晨光计划资助项目(200850731401) |
| |
| 摘 要： | 天然孕甾烷-17(20)-烯中C-17位双键的构型对分子的药理性质有重要的影响，但是采用化学位移比较等方法判断其构型存在费时以及区分模糊等缺点. 该文以E-和Z-guggulsterone为模型化合物，利用一维选择性NOE实验来进行天然孕甾烷-17(20)-烯中C-17位双键的构型测定. 由于空间相对位置受到构型影响，选择反转20位的质子时，如果选择性NOE谱中仅能检测到21位甲基氢，表明该化合物为E-构型；如果除了21位甲基氢外，18位甲基氢和12位氢也存在于选择性NOE谱中，则表明该化合物为Z-构型. 实验结果表明该方法具有区分度大，简单快速等优点，可以普遍适用于这些孕甾烷类化合物17位双键构型的确定.
|
| 关 键 词： | 核磁共振(NMR) 构型 选择性NOE 孕甾烷-17(20)-烯 |
| 收稿时间： | 2010-04-01 |
| 修稿时间： | 2010-04-15 |
Rapid Configuration Determination of Carbon-17 Ethylene Bond in Natural Pregn-17(20)-ene |
| |
| JIANG Hai-peng,JIANG Xian-wang,ZHANG Xu,LIU Mai-li.Rapid Configuration Determination of Carbon-17 Ethylene Bond in Natural Pregn-17(20)-ene[J].Chinese Journal of Magnetic Resonance,2011,28(1):93-98. |
| |
| Authors: | JIANG Hai-peng JIANG Xian-wang ZHANG Xu LIU Mai-li |
| |
| Institution: | JIANG Hai-peng1,2,JIANG Xian-wang1,ZHANG Xu1,LIU Mai-li1[1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan Center of Magnetic Resonance,(Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences),Wuhan 430071,China,2.Graduate School of the Chinese Academy of Sciences,Beijing 100049,China] |
| |
| Abstract: | The configuration of carbon-17 ethylene bond in pregn-17(20)-ene derivatives has important influence on the pharmacological properties of the compounds.However,the previously used methods for configuration determination of pregn-17(20)-ene derivatives either are time consuming or cannot obtain certain results.In this paper,we proposed to use 1D selective NOESY to determine the configuration of carbon-17 ethylene bond in E-and Z-guggulsterone.The results showed that,by selective inversion of H-20,the NOE spe... |
| |
| Keywords: | NMR configuration selective NOESY pregn-17(20)-ene |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《波谱学杂志》浏览原始摘要信息 |
| 点击此处可从《波谱学杂志》下载免费的PDF全文 |
|
