| Motile parameters of cell migration in anisotropic environment derived by speed power spectrum fitting with double exponential decay |
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| 作者姓名： | 刘艳平 李翔 屈静 高学娟 何情祖 刘雳宇 刘如川 帅建伟 |
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| 作者单位： | Department of Physics;State Key Laboratory of Cellular Stress Biology.Innovation Center for Cell Signaling Network.Xiamen University;College of Physics;National Institute for Big Data in Healthcare at Xiamen University |
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| 基金项目： | supported by the Na-tional Natural Science Foundation of China(Grant Nos.11675134,11874310,11474345,and 11604030);the 111 Project(Grant No.B160229);the China Postdoctoral Science Foundation(Grant No.2016M602071). |
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| 摘 要： | Cell migration through anisotropic microenvironment is critical to a wide variety of physiological and pathological processes.However,adequate analytical tools to derive motile parameters to characterize the anisotropic migration are lacking.Here,we proposed a method to obtain the four motile parameters of migration cells based on the anisotropic persistent random walk model which is described by two persistence times and two migration speeds at perpendicular directions.The key process is to calculate the velocity power spectra of cell migration along intrinsically perpendicular directions respectively,then to apply maximum likelihood estimation to derive the motile parameters from the power spectra fitting with double exponential decay.The simulation results show that the averaged persistence times and the corrected migration speeds can be good estimations for motile parameters of cell migration.
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| 关 键 词： | cell migration HETEROGENEITY power spectrum random WALK LANGEVIN equation |
Motile parameters of cell migration in anisotropic environment derived by speed power spectrum fitting with double exponential decay |
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| Yan-Ping Liu,Xiang Li,Jing Qu,Xue-Juan Gao,Qing-Zu He,Li-Yu Liu,Ru-Chuan Liu,Jian-Wei Shuai.Motile parameters of cell migration in anisotropic environment derived by speed power spectrum fitting with double exponential decay[J].Frontiers of Physics,2020,15(1):13602-61. |
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| Authors: | Yan-Ping Liu Xiang Li Jing Qu Xue-Juan Gao Qing-Zu He Li-Yu Liu Ru-Chuan Liu Jian-Wei Shuai |
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| Institution: | 1. Department of Physics, Xiamen University, Xiamen 361005, China2. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, Xiamen University, Xiamen 361102, China3. College of Physics, Chongqing University, Chongqing 401331, China4. National Institute for Big Data in Healthcare at Xiamen University, Xiamen 361102, China |
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| Abstract: | Cell migration through anisotropic microenvironment is critical to a wide variety of physiological and pathological processes. However, adequate analytical tools to derive motile parameters to characterize the anisotropic migration are lacking. Here, we proposed a method to obtain the four motile parameters of migration cells based on the anisotropic persistent random walk model which is described by two persistence times and two migration speeds at perpendicular directions. The key process is to calculate the velocity power spectra of cell migration along intrinsically perpendicular directions respectively, then to apply maximum likelihood estimation to derive the motile parameters from the power spectra fitting with double exponential decay. The simulation results show that the averaged persistence times and the corrected migration speeds can be good estimations for motile parameters of cell migration. |
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| Keywords: | cell migration heterogeneity power spectrum random walk Langevin equation |
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