| 新光敏剂铝酞菁与人癌细胞作用的荧光研究 |
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| 引用本文： | 陈既耀,闵红波.新光敏剂铝酞菁与人癌细胞作用的荧光研究[J].发光学报,1990,11(1):49-54. |
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| 作者姓名： | 陈既耀 闵红波 |
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| 作者单位： | 1. 复旦大学物理系;2. 第二军医大学病理解剖教研室 |
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| 摘 要： | 本文对用于光动力癌症疗法(PPT)的新光敏剂铝酞菁(AlSPC)与人癌细胞的作用进行了实验探讨。细胞荧光光谱的测定及荧光强度的定量表明,铝酞菁能被人癌细胞所吸收,且经40μg/mlAlSPC培育24小时后,细胞对AlSPC吸收的量级为3.47μg/107细胞。对人癌细胞的光敏杀伤显示,杀伤效果正比于光敏剂培育浓度与光辐照剂量。由脂质过氧化的荧光研究表明,经光敏反应后人癌细胞膜的脂质过氧化代谢产物丙二醛(MDA)明显增高,揭示在AlSPC光敏反应中有活性氧作用。色氨酸降解的荧光实验证实,在光敏反应中有单线态氧(1O2)的生成。
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| 关 键 词： | 光敏剂 人体 癌细胞 铝酞菁 荧光 |
| 收稿时间： | 1989-08-16 |
A FLUORESCENCE STUDY ON PHOTOSENSITIZATION OF HUMAN CANCER CELLS WITH NEW PHOTOSENSITIZER-SULFONATED ALUMINUM PHTHALOCYANINE(AlSPC) |
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| Chen Jiyao,Min Hongbo,L&#,Fadu,Dong Rongchun,Cai Huaixin.A FLUORESCENCE STUDY ON PHOTOSENSITIZATION OF HUMAN CANCER CELLS WITH NEW PHOTOSENSITIZER-SULFONATED ALUMINUM PHTHALOCYANINE(AlSPC)[J].Chinese Journal of Luminescence,1990,11(1):49-54. |
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| Authors: | Chen Jiyao Min Hongbo L&# Fadu Dong Rongchun Cai Huaixin |
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| Institution: | 1. Physics Department of Fudan University;2. Pathology Department of Second Military Medical College |
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| Abstract: | Photodynamic cancer therapy (PDT) is a hopeful means to tieat cancer. Instead of HPD, recently some new photosensitizers have been developed. Among them phthalocyanine (PC) are most noticed, because it is pure chemical, rather stable, and is absorbed more strongly in red region (the best penetration wave-band of human tissue).After we synthesized sulfonated aluminum phthalocyanine (AlSPC) in our laboratory and found out its photokilling ability to human liver cancer line (SMMC-7721), the continuous study on photosensitization of SMMC-7721 cell line with AlSPC using fluorescence technic is reported in this paper. |
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