Cavitation-enhanced delivery of macromolecules into an obstructed vessel |
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Authors: | Rifai Bassel Arvanitis Costas D Bazan-Peregrino Miriam Coussios Constantin-C |
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Institution: | Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford OX1 3PJ, United Kingdom. bassel.rifai@eng.ox.ac.uk |
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Abstract: | Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The aim of this study was to examine the ability of cavitation instigated by high-intensity focused ultrasound (HIFU) to increase convective transport of a model therapeutic in an in vitro tumor model. Cavitation activity was quantified by analyzing passively recorded acoustic emissions, and mass transfer was quantified using post-treatment image analysis of the distribution of a dye-labeled macromolecule. The strong correlation between cavitation activity and drug delivery suggests the potential for non-invasive treatment and monitoring. |
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