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Fabrication of silk sericin/alginate microparticles by electrohydrodynamic spraying technique for the controlled release of silk sericin
Institution:1. Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, PhayaThai Road, Phatumwan, Bangkok 10330, Thailand;2. Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, PhayaThai Road, Phatumwan, Bangkok 10330, Thailand;1. Laboratory of Phytoprotection Science and Technology, Faculty of Agriculture, Kinki University, Nara 631-8505, Japan;2. Pharmaceutical Research and Technology Institute, Kinki University, Osaka 577-8502, Japan;3. Research and Development Division, Kagome Co., Ltd., Tochigi 329-2762, Japan;4. Technical Development Unit, Panasonic Environmental Systems & Engineering Co., Ltd., Osaka 564-0062, Japan;5. Agricultural, Food and Environmental Sciences Research Center of Osaka Prefecture, Osaka 583-0862, Japan;1. Electrical Engineering Laboratory, 8 May 1945 University, Guelma 24000, Algeria;2. PPRIME Institute, UPR 3346, CNRS University of Poitiers – ENSMA, IUT d''Angoulême, 4 Av. de Varsovie, 16021 Angoulême, France;1. Young Researchers and Elite Club, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran;2. Esfarayen University, Engineering and Technical College, Mechanical Engineering Department, Esfarayen North Khorasan, Iran;3. Department of Mechanical Engineering, Yazd University, Yazd, Iran;4. Department of Mechanical Engineering, Babol University of Technology, Babol, Iran
Abstract:Silk sericin has been recently investigated for many biological roles. This study aimed to develop the new delivery system to control the release of silk sericin. The alginate microparticles encapsulating silk sericin were fabricated by electrospraying technique. Concentrations of silk sericin and alginate polyelectrolyte solutions were investigated. All microparticles had an average size of 264–284 μm and could entrap silk sericin with high entrapment efficiency (84–89%). The microparticles could deliver silk sericin in a rate-controlled manner. This study would show a promising controlled release application of silk sericin protein from alginate microparticles fabricated by the means of electrostatic forces.
Keywords:Silk sericin  Alginate  Microparticle  Electrospraying  Electrostatic force  Drug delivery
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