Microlens array recording of localized retinal responses |
| |
Authors: | Zhang Qiu-Xiang Wang Jin-Yu Liu Lei Yao Xin-Cheng |
| |
Institution: | Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. |
| |
Abstract: | We designed a rapid functional imager for the parallel recording of localized intrinsic optical signals (IOSs). This imager used a microlens array (MLA)-based illuminator to deliver visible stimulus light and near-infrared (NIR) recording light simultaneously. The parfocal configuration of the stimulus and recording light illumination enabled confocal recording of the stimulus-evoked IOSs. Because the MLA stimulation/recording spots were widely separated on the retina, and only the photoreceptors within the MLA stimulation/recording spots were stimulated, the potential IOS cross talk effect among neighboring retinal areas was minimized. Our experiments revealed robust IOS activities tightly correlated with localized retinal responses. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|