High-resolution in vivo imaging of blood vessels without labeling |
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Authors: | Fu Dan Ye Tong Matthews Thomas E Chen Benny J Yurtserver Gunay Warren Warren S |
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Institution: | Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. dfu@princeton.edu |
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Abstract: | We demonstrate that both oxyhemoglobin and deoxyhemoglobin have sequential two-color, two-photon absorption properties that can serve as endogenous contrasts in microvasculature imaging. Using a sensitive modulation transfer technique, we are able to image hemoglobin in red blood cells with micrometer resolution, both in vitro and in vivo. We show that excellent contrast from hemoglobin without any labeling can be obtained in tissue. |
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