Multiharmonic-generation biopsy of skin |
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| Authors: | Sun Chi-Kuang Chen Cheng-Chi Chu Shi-Wei Tsai Tsung-Han Chen Yung-Chih Lin Bai-Ling |
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| Institution: | Department of Electrical Engineering and Graduate Institute of Electro-Optical Engineering, National Taiwan University, Taipei 10617, Taiwan. sun@cc.ee.ntu.edu.tw |
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| Abstract: | Because it avoids the in-focus photodamage and phototoxicity problem of two-photon-fluorescence excitation, multiharmonic-generation biopsy based on a 1200-1300-nm light source could provide a truly noninvasive and highly penetrative optical sectioning of skin. We study multiharmonic-generation biopsy of fixed mouse skin. Our preliminary study suggests that this technique could provide submicrometer-resolution deep-tissue noninvasive biopsy images in skin without the use of fluorescence and exogenous markers. |
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