| 关于药物对小鼠肝脏细胞色素P-450含量的影响实验结果的分析 |
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| 引用本文： | 张潇,高东红.关于药物对小鼠肝脏细胞色素P-450含量的影响实验结果的分析[J].数学的实践与认识,2006,36(1):102-104. |
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| 作者姓名： | 张潇 高东红 |
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| 作者单位： | 1. 北京大学医学部临床003班,北京,100083
2. 北京大学医学部生物数学与生物统计教研室,北京,100083 |
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| 摘 要： | 肝药酶诱导剂苯巴比妥能诱导细胞色素P-450的合成,而肝药酶抑制剂放线菌素D能抑制细胞色素P-450的合成,本实验应用示差光谱法对P-450含量加以测定.本文改进了传统的计算药后诱导组和抑制组P-450含量增加或减少的百分比来评价药物的方法,在M athem atica数学软件环境下,对数据进行方差分析和t检验,提高了数据处理精度和可信度.并对原方法表示怀疑.
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| 关 键 词： | 肝药酶 诱导剂 抑制剂 方差分析 t检验 |
| 修稿时间： | 2003年2月25日 |
About the Analysis of Influence of Drugs on the Hepatic Cytochrome P-450 Content of Mice |
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| ZHANG Xiao,GAO Dong-hong.About the Analysis of Influence of Drugs on the Hepatic Cytochrome P-450 Content of Mice[J].Mathematics in Practice and Theory,2006,36(1):102-104. |
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| Authors: | ZHANG Xiao GAO Dong-hong |
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| Abstract: | The inducer of hepatic cytochrome P-450,phenobarbital sodium,can induce the synthesis of cytochrome P-450,while The inhibitor of hepatic cytochrome P-450,antimycin D,can inhibit the synthesis of it.In this experiment,we measured the content of hepatic cytochrome P-450 of mice.Here,I improved the traditional method of calculating the percentage of increase or decrease of the content of hepatic cytochrome P-450 of mice,while analyzed the data with ANOVA(analysis of variance) and HypothesisTests,in order to make the result more convincing. |
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| Keywords: | hepatic cytochrome inducer inhibitor ANOVA test |
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