| 冠状动脉狭窄情况下的非牛顿血液流动和大分子传质 |
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| 引用本文： | 李新宇,温功碧,李丁.冠状动脉狭窄情况下的非牛顿血液流动和大分子传质[J].应用数学和力学,2001,22(4):359-372. |
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| 作者姓名： | 李新宇 温功碧 李丁 |
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| 作者单位： | 北京大学力学和工程科学系, 湍流研究国家重点实验室, 北京100871 |
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| 基金项目： | 国家自然科学基金重点资助项目(19732003) |
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| 摘 要： | 针对冠状动脉狭窄的情况,采用数值模拟方法求解了牛顿流体与非牛顿流体(幂次律流体和Casson流体)的定常与脉动的流场。在此基础上,求解了LDL(低密度脂肪蛋白)和Albumin(血清白蛋白)的浓度场。根据计算结果,详细讨论了壁面剪应力、非牛顿流效应、分子大小等因素对大分子传质的影响;并对牛顿流体与非牛顿流体、定常流动与脉动流动的大分子浓度场进行了比较,这些结果对于了解动脉硬化成因与流动特性和大分子传质的联系提供了较为丰富的信息。
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| 关 键 词： | 动脉粥样硬化 非牛顿流 大分子传质 壁面剪应力 |
| 文章编号： | 1000-0887(2001)04-0359-14 |
| 收稿时间： | 1999-08-12 |
| 修稿时间： | 1999年8月12日 |
Computer Simulation of
Non_Newtonian Flow and Mass Transport Through Coronary Arterial Stenosis |
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| LI Xin_yu,WEN Gong_bi,LI Ding.Computer Simulation of
Non_Newtonian Flow and Mass Transport Through Coronary Arterial Stenosis[J].Applied Mathematics and Mechanics,2001,22(4):359-372. |
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| Authors: | LI Xin_yu WEN Gong_bi LI Ding |
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| Institution: | Mechanics and Engineering Science Department, Peking University, Beijing 100871, P R China |
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| Abstract: | A numerical analysis of Newtonian and non_Newtonian flow in an axi_symmetric tube with a local constriction simulating a stenosed artery under steady and pulsatile flow conditions was carried out. Based on these results, the concentration fields of LDL (low_density lipoprotein) and Albumin were discussed . According to the results, in great details the macromolecule transport influences of wall shear stress, non_Newtonian fluid character and the scale of the molecule etc are given. The results of Newtonian fluid flow and non_Newtonian fluid flow, steady flow and pulsatile flow are compared. These investigations can provide much valuable information about the correlation between the flow properties, the macromolecule transport and the development of atherosclerosis. |
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| Keywords: | atherosclerosis non-Newtonian fluid flow macromolecule transport wall shear stress |
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