| 抗血管生成治疗抑制实体肿瘤细胞生长的数值模拟:应用血管生成与肿瘤生长的耦合数学模型 |
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| 引用本文： | 蔡彦,吴洁,许世雄,龙泉,姚伟.抗血管生成治疗抑制实体肿瘤细胞生长的数值模拟:应用血管生成与肿瘤生长的耦合数学模型[J].应用数学和力学,2011,32(10):1199-1207. |
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| 作者姓名： | 蔡彦 吴洁 许世雄 龙泉 姚伟 |
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| 作者单位： | 1.复旦大学 力学与工程系,上海 200433; |
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| 基金项目： | 国家自然科学基金资助项目(1037202610772051); 上海市重点学科建设资助项目(B112) |
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| 摘 要： | 为研究抗血管生成因子angiostatin和抗血管生成药物endostatin对肿瘤血管生成和肿瘤细胞的抑制作用，建立耦合肿瘤血管生长、肿瘤生长和血液灌注的数学模型．模拟结果显示抗血管生成因子angiostatin和抗血管生成药物endostatin可明显抑制血管生成和减少肿瘤细胞数量，从而起到改善肿瘤组织内部异常微环境的作用．模型可作为肿瘤抗血管生成治疗的一种理论研究．
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| 关 键 词： | 肿瘤血管生成 肿瘤生长 抗血管生成治疗 耦合数学模型 |
| 收稿时间： | 2011-01-14 |
Numerical Simulation of the Inhibiting Effects on Solid Tumour Cells in Anti-Angiogenic Therapy: an Application of Coupled Mathematical Model of Angiogenesis With Tumour Growth |
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| CAI Yan,WU Jie,XU Shi-xiong,LONG Quan,YAO Wei.Numerical Simulation of the Inhibiting Effects on Solid Tumour Cells in Anti-Angiogenic Therapy: an Application of Coupled Mathematical Model of Angiogenesis With Tumour Growth[J].Applied Mathematics and Mechanics,2011,32(10):1199-1207. |
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| Authors: | CAI Yan WU Jie XU Shi-xiong LONG Quan YAO Wei |
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| Institution: | 1.Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, P. R. China;School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiaotong University, Shanghai 200240, P. R. China;Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK |
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| Abstract: | To investigate the inhibiting effects of anti-angiogenic factor angiostatin and anti-angiogenic drug endostatin on tumour angiogenesis and tumour cells,a coupled mathematical model of tumor angiogenesis with tumour growth and blood perfusion was developed.The simulation results showed that angiostatin and endostatin could improve the abnormal microenvironment inside the tumour tissue,by effectively inhibiting the process of tumor angiogenesis and decreasing the number of tumour cells.The present model can b... |
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| Keywords: | tumor angiogenesis tumor growth anti-angiogenic therapy coupled mathematical model |
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