On computation of the steady-state probability distribution of probabilistic Boolean networks with gene perturbation |
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Authors: | Wen Li Lu-Bin Cui Michael K Ng |
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Institution: | 1. School of Mathematical Sciences, South China Normal University, Guangzhou, 510631, China;2. Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong |
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Abstract: | Given a Probabilistic Boolean Network (PBN), an important problem is to study its steady-state probability distribution for network analysis. In this paper, we present a new perturbation bound of the steady-state probability distribution of PBNs with gene perturbation. The main contribution of our results is that this new bound is established without additional condition required by the existing method. The other contribution of this paper is to propose a fast algorithm based on the special structure of a transition probability matrix of PBNs with gene perturbation to compute its steady-state probability distribution. Experimental results are given to demonstrate the effectiveness of the new bound, and the efficiency of the proposed method. |
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Keywords: | Structured matrices Probabilistic Boolean networks Steady-state probability distribution Perturbation bound Iterative methods |
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