Study on the hydrolytic degradation of the segmented GL-b-[GL-co-TMC-co-CL]-b-GL copolymer with application as monofilar surgical suture |
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| Authors: | Yolanda Márquez Lourdes Franco Pau Turon Alfonso Rodríguez-Galán Jordi Puiggalí |
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| Institution: | 1. Departament d''Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona E-08028, Spain;2. B. Braun Surgical, S.A. Carretera de Terrasa 121, Rubí, Barcelona 08191, Spain |
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| Abstract: | The hydrolytic degradation of Monosyn™, a segmented copolymer derived from glycolide, trimethylene carbonate and ε-caprolactone, has been evaluated in buffered aqueous media at different pH and temperature. Degradation processes have been followed by considering mass loss and molecular weight profiles as well as the changes on 1H NMR and FTIR spectra, morphology and both calorimetric and mechanical properties during exposure to the selected media and temperature. |
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| Keywords: | Polyglycolide Poly(trimethylene carbonate) Bioabsorbable surgical sutures Hydrolytic degradation Polymer microstructure |
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