Thermal
decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate |
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Authors: | B A Howell D Fan Leela Rakesh |
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Institution: | (1) Center for Applications in Polymer Science, Central Michigan University, Mt. Pleasant, USA, 48859-0001, MI |
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Abstract: | A nanoscale
multivalent platinum drug based on a poly(amidoamine) PAMAM] dendrimer (generation
4.5, carboxylate surface) has been synthesized and fully characterized using
a variety of spectroscopic, chromatographic and thermal methods. Treatment
of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces
a conjugate containing approximately forty (diaminocyclohexane)platinum(II)
moieties at the surface of the dendrimer. This material undergoes smooth two-stage
thermal decomposition to provide residual platinum oxide reflecting the platinum
loading in the drug. |
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Keywords: | dendrimer-based organoplatinum drugs drug delivery polymeric drugs thermal decomposition time-release drugs |
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