A sensitive non-enzymatic glucose sensor in alkaline media based on Cu/MnO2-modified glassy carbon electrode

A novel and simple glucose sensor based on layer-by-layer (LBL) assembly of Cu and MnO₂ nanoparticles on the glassy carbon electrode (Cu/MnO₂/GCE) was constructed. The morphology and composition of the Cu and Cu/MnO₂ on the electrode surface were observed by scanning electron microscopy and X-ray diffraction. Electrochemical experiments showed that the proposed Cu/MnO₂/GCE exhibited excellent electrocatalytic properties to glucose. The oxidation peak currents of glucose on the Cu/MnO₂/GCE were linearly related to glucose concentration in a wider linearity range from 0.25???M to 1.02?mM with a correlation coefficient of 0.9977. The sensitivity and detection limit was 26.96???A?mM^?1 and 0.1???M (S/N?=?3), respectively. The Cu/MnO₂ nanocomposite-modified electrode presented attractive features such as high sensitivity, stability, reproducibility, and interference-free property. The applicability of the proposed method to the determination of glucose in serum samples was demonstrated with satisfactory results.