A ruthenium-catalyzed one-pot method for α-alkylation of ketones with aldehydes |
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| Authors: | Chan Sik Cho Sang Chul Shim |
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| Institution: | a Research Institute of Industrial Technology, Kyungpook National University, 1370 Sankyuk-dong, Puk-ku, Daegu 702-701, Republic of Korea
b Department of Applied Chemistry, College of Engineering, Kyungpook National University, Daegu 702-701, Republic of Korea |
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| Abstract: | Ketones react with an array of aldehydes in dioxane at 80 °C in the presence of a catalytic amount of RuCl2(PPh3)3 along with KOH to give the corresponding α-alkylated ketones in moderate to good yields. A reaction pathway involving base-catalyzed cross-aldol reaction between ketones and aldehydes to form α,β-unsaturated ketones and regioselective reduction of carbon-carbon double bond of α,β-unsaturated ketones is proposed for this catalytic process. |
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| Keywords: | Aldehydes Aldol reaction α-alkylation Ketones Reduction Ruthenium catalyst |
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