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| A Novel and Convenient Assay for the Determination of OH Produced by Fenton Reaction | |
| 引用本文： | Zhuo Bin YUAN, Zhi Ru MA(Department of Chendstry,Graduate School,USTC,Academia Sinica,Beijing 100039). A Novel and Convenient Assay for the Determination of OH Produced by Fenton Reaction[J]. 中国化学快报, 1998, 0(6) |
| 作者姓名： | Zhuo Bin YUAN Zhi Ru MA(Department of Chendstry Graduate School USTC Academia Sinica Beijing 100039) |
| 作者单位： | Department of Chendstry，Graduate School，USTC，Academia Sinica，Beijing 100039 |
| 摘 要： | Oxygenradicalsaswellas0theroxygen-derivedspeciesincludinglipidperoxides,havebeensuggestCdaspotentiallyimportantcausativeagents0fagingandvarioushumandi,...,i-3suchascancer,multiplescler0sis,Parkinson'sdisease,autoinununediseases,ischemia,anemia,seniledementiaandasbestosis.Am0ngthevari0usradicals,thehydroxylradical(OH)ispresumedtoplayacentralroleduetoitSstr0ngactivity'.TheimPortanceofremovingexcessiveactiveoxygenspeciesfromlivingorganismsisbecondngincreasinglyrec0gnized,t0getherwithagrowingint… |
A Novel and Convenient Assay for the Determination of OH Produced by Fenton Reaction |
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| Zhuo Bin YUAN, Zhi Ru MA. A Novel and Convenient Assay for the Determination of OH Produced by Fenton Reaction[J]. Chinese Chemical Letters, 1998, 0(6) | |
| Authors: | Zhuo Bin YUAN Zhi Ru MA |
| Abstract: | A novel, simple and convenient method for the determination of hydroxyl radicals isestablished. Hydroxyl radicals produced by Fenton reaction is trapped by spin trap reagent phenyl-t-butyl nitrone (PBN), and the free radical adduct of PBN can be detected by single sweeposcillopolarography, with its second order derivative cathodic wave at -0.52V vs SCE. Theoptimum experimental conditions for the detemination is discussed, and the scavenging effects ofsome compounds on OH was also studied. |
| Keywords: | hydroxyl radicals Fenton reaction spin trap reagent PBN electrochemical method |
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