Determination of acetaminophen by square wave voltammetry at a gold electrode modified by 4-amino-2-mercaptopyrimidine self-assembled monolayers |
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Authors: | Li Jia X -H Zhang Q Li S -F Wang |
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Institution: | (1) Faculty of Chemistry and Material Science, Hubei University, Wuhan, 430062, China |
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Abstract: | A 4-Amino-2-mercaptopyrimidine self-assembled monolayer (AMP SAMs/Au) modified gold electrode was prepared. The electrochemical
behavior of acetaminophen on the AMP SAMs/Au was studied in Britton-Robinson (BR) buffer solution. Compared to a bare gold
electrode, the modified electrode exhibits a significant enhancement in the oxidation current response for acetaminophen.
The modified electrode was used for the determination of acetaminophen by square wave voltammetry. The oxidation current increased
linearly with the concentration of acetaminophen in the range of 2.0 × 10−6−4.0 × 10−3 M. The modified electrode made it possible to eliminate the interference of dopamine (DA), brucine, epinephrine (EP), and
norepinephrine (NE). The practical analytical utility was illustrated by the determination of acetaminophen in a commercially
available drug.
The text was submitted by the authors in English. |
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