An efficient and facile synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine |
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| Authors: | Sheng Xia Shan Yin Shimin Tao Yanhui Shi Liangce Rong Xianyong Wei Zhimin Zong |
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| Institution: | 1. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, People’s Republic of China
2. School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou, 221006, Jiangsu, People’s Republic of China
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| Abstract: | One-pot, multicomponent reaction for the synthesis of novel substituted pyrimidine derivatives: 4-amino-5-carbonitrile-2-nitroaminopyrimidine from aromatic aldehydes, 1-nitroguanidine, and malononitrile under ethanol is described. Because of containing many active functional groups, such as amino, cyan and nitro, these products are important intermediate of organic synthesis. The advantages of this procedure include the short reaction time, mild reaction conditions, and excellent yields. |
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