| Synthesis of thiopyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines |
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| 作者姓名： | Essam Kh. Ahmed Mohamed A. Ameen |
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| 作者单位： | Chemistry Department, Faculty of Science, El Minia University, El Minia 61519, Egypt |
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| 摘 要： | <正>Reactions of the 6-hydroxy-thiopyrano3,4-c]pyridine-5-carbonitrile derivative 1 withα-halo-carbonyl compounds gave the ortho-substituted intermediates 2a-c which were converted into furo2,3-b]thiopyrano4,3-d]pyridines 3a-c by fusion of a furan moiety under basic conditions.Further cyclization of 3a-c led to a fusion of a pyrimidine ring,yielding the tetracyclic products 6,7 and 8.In addition,condensation of 6 with various aromatic aldehydes afforded the corresponding imines 9a,b.Mannich reaction of 7 gave products 10a,b.
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| 收稿时间： | 23 September 2009 |
Synthesis of thiopyrano[4',3':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidines |
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| Essam Kh. Ahmed,Mohamed A. Ameen.Synthesis of thiopyrano[4',3':4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidines[J].Chinese Chemical Letters,2010,21(6):669-673. |
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| Authors: | Essam KhAhmed Mohamed AAmeen Chemistry |
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| Institution: | Chemistry Department, Faculty of Science, El Minia University, El Minia 61519, Egypt |
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| Abstract: | Reactions of the 6-hydroxy-thiopyrano3,4-c]pyridine-5-carbonitrile derivative 1 with α-halo-carbonyl compounds gave the ortho-substituted intermediates 2a-c which were converted into furo2,3-b]thiopyrano4,3-d]pyridines 3a-c by fusion of a furan moiety under basic conditions. Further cyclization of 3a-c led to a fusion of a pyrimidine ring, yielding the tetracyclic products 6,7 and 8. In addition, condensation of 6 with various aromatic aldehydes afforded the corresponding imines 9a,b. Mannich reaction of 7 gave products 10a,b. |
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| Keywords: | S N-Heterocycles S N O-Heterocyles Furo[2 3-b]thiopyrano[4 3-d]pyridine Thiopyranopyridofuropyrimidines |
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