Milde alkalische Hydrolyse von Aconitin

Mild Alkaline Hydrolysis of Aconitine Hydrolysis of aconitine ( 1 ) with 0.04N K₂CO₃ in 90% MeOH at room temperature yields, besides the alkamine aconine 3 considerable amounts of 8-O-methylaconine ( 6 ) and smaller quantities of desbenzoyl-pyroaconitine ( 4 ) and 16-epi-desbenzoyl-pyroaconitine ( 5 ). Better yields of 4 and 5 are obtained when heating a solution of aconitine in 0.04N K₂CO₃ in 90% EtOH.