Convenient synthesis of α-trifluoromethyl amines via aminofluoroalkylation of arenes with N-trimethylsilyl α-trifluoroacetaldehyde hemiaminal |
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Authors: | Yuefa Gong |
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Institution: | National Institute of Advanced Industrial Science and Technology (AIST), 2266-98 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-8560, Japan |
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Abstract: | Aminofluoroalkylation of various heteroarenes or substituted benzenes with the N-trimethylsilyl hemiaminals, prepared from 1,1,1,3,3,3-hexamethyldisilazane and gaseous trifluoroacetaldehyde, smoothly underwent at room temperature in the presence of a Lewis acid. (1-Aryl-2,2,2-trifluoro)ethyl]amines or bis(1-aryl-2,2,2-trifluoro)ethyl]amines were afforded in moderate to high yields. |
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Keywords: | Aminofluoroalkylation Trifluoroacetaldehyde α-Trifluoromethyl amine 1 1 1 3 3 3-Hexamethyldisilazane |
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