Recyclization of 1,4-dihydropyridine derivatives in acidic medium |
| |
Authors: | S Stupnikova E Petushkova D Muceniece V Lūsis |
| |
Institution: | (1) Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia |
| |
Abstract: | The recyclization of 1,4-dihydropyridines in aqueous-alcoholic hydrochloric acid medium proceeds with cleavage of a C-N bond
and pyridine ring opening. Cyclohexenone derivatives are formed as a result of the subsequent intramolecular crotonic condensation
of the acyclic intermediate. The leaving carbonyl substituents depart simultaneously with recyclization, depending on the
acidity of the reaction medium.
Dedicated to Prof. Dr. E. Lukevics on the occasion of his 70th birthday.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 49–58, January, 2007. |
| |
Keywords: | 1 4-dihydropyridines cyclohex-2-enones recyclization hydrolysis of enamines elimination of carbonyl substituents |
本文献已被 SpringerLink 等数据库收录! |
|