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Highly Enantioselective Ring‐Opening Reactions of Aziridines with Indole and Its Application in the Building of C3‐Halogenated Pyrroloindolines |
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| Authors: | Fengxia Han Dan Li Dr Depeng Zhao Dr Yiming Cao Yunxia Ma Weidong Kong Quantao Sun Prof?Dr Rui Wang |
| Institution: | 1. School of Life Sciences, Lanzhou University, Lanzhou, 730000 (P. R. China);2. State Key Laboratory of Chiroscience, Department of Applied, Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong (P. R. China) |
| Abstract: | A magnesium‐catalyzed asymmetric ring‐opening reaction of aziridine with indole has been realized by employing commercially available chiral ligands. Both of the enantiomers of the ring‐opening product could be obtained with good yields and a high level of enantioselectivity. The corresponding ring‐opening product could be further transformed to various types of enantioenriched C3‐halogenated‐pyrroloindolines. |
| Keywords: | asymmetric synthesis cyclization magnesium ring‐opening reactions |