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Expedient Synthesis of Chiral α‐Amino Acids through Nickel‐Catalyzed Reductive Cross‐Coupling |
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| Authors: | Xi Lu Jun Yi Zhen‐Qi Zhang Jian‐Jun Dai Jing‐Hui Liu Prof. Bin Xiao Prof. Yao Fu Prof. Lei Liu |
| Affiliation: | 1. Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China);2. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China);3. Department of Chemistry, Tsinghua University, Beijing 100084 (China) |
| Abstract: | A novel method for the synthesis of non‐natural L ‐ and D ‐amino acids by a Ni‐catalyzed reductive cross‐coupling reaction is described. This strategy enables the racemization‐free cross‐coupling of serine/homoserine‐ derived iodides with aryl/acyl/alkyl halides. It provides convenient access to varieties of enantiopure and functionalized amino acids, which are important building blocks in bioactive compounds and pharmaceuticals. |
| Keywords: | amino acids catalysis C C bond formation nickel reductive cross‐coupling |