Combining [Arene–Ru] with Azocarboxamide to Generate a Complex with Cytotoxic Properties |
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| Authors: | Michael G Sommer Petra Kureljak Dr Damijana Urankar Dr David Schweinfurth Nikolina Stojanovi? Dr Martina Bubrin Dr Martin Gazvoda Dr Maja Osmak Prof?Dr Biprajit Sarkar Prof?Dr Janez Ko?mrlj |
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| Institution: | 1. Institut für Chemie und Biochemie, Anorganische Chemie, Freie Universit?t Berlin, Fabeckstra?e 34–36, 14195, Berlin (Germany);2. Division of Molecular Biology, Ru?er Bo?kovi? Institute, Bijeni?ka cesta 54, HR‐10000 Zagreb (Croatia);3. Faculty of Chemistry and Chemical Technology, University of Ljubljana, A?ker?eva 5, SI‐1000, Ljubljana (Slovenia) |
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| Abstract: | Azocarboxamide (azcH) has been combined for the first time with Ru–Cym] to generate metal complexes with N,N‐ and N,O‐coordination mode, (Cym)Ru(azc)Cl] and (Cym)Ru(azcH)Cl]+PF6]?. Geometric and electronic structures of the complexes are reported along with their in vitro activities against different tumour cell lines and preliminary results on solution chemistry. Compound (Cym)Ru(azc)Cl] exhibited remarkable cytotoxic properties. It was cell‐type specific and had comparable IC50 values towards both cancer cells and their drug‐resistant subline. A tenfold increase in the sensitivity towards (Cym)Ru(azc)Cl] was noted for the tumour cells with depleted intracellular glutathione (GSH) level, suggesting the essential role of GSH in cell response to this compound. |
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| Keywords: | antitumor agents azocarboxamide N N ligands N O ligands ruthenium |
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