Raman reporter-coated gold nanorods and their applications in multimodal optical imaging of cancer cells |
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Authors: | Jiang Li Qian Jun Cai Fuhong He Sailing |
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Institution: | (1) Centre for Optical and Electromagnetic Research, State Key Laboratory of Modern Optical Instrumentations, Zhejiang University, Hangzhou, 310058, China;(2) Joint Research Center of Photonics of the Royal Institute of Technology (Sweden) and Zhejiang University, Hangzhou, 310058, China; |
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Abstract: | We report the preparation of a kind of surface-enhanced Raman scattering (SERS) tags and explore their applications in multifunctional
optical imaging of cancer cells. The proposed nanoparticles (SERS tags) are prepared by connecting dye molecules directly
onto the surfaces of gold nanorods through Au–S or Au–N interactions. The dye molecules are used as Raman reporters, while
gold nanorods are used as enhanced materials due to their localized surface plasmon resonance effect. Multilayered polymers
are further coated onto the surfaces of the nanoparticles to reach better stability and biocompatibility. Gold nanorods with
different aspect ratios and different dye molecules conjugated are compared in order to achieve the diversity of SERS tags
and find out the optimized condition of SERS tags with the highest signal intensity. Our experiments show that the resulting
nanoparticles, which are uptaken by cancer cells, can provide not only dark field cells images but also multiplexing SERS
images. |
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