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An efficient synthesis of pyrazole chalcones under solvent free conditions at room temperature |
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| Authors: | Parvin Kumar Sunil Kumar Khalid Husain Ashwani Kumar |
| Institution: | a Chemistry Department, Guru Nanak Khalsa College, Haryana 135001, India;b Chemistry Department, Government College, Haryana 125001, India;c Drug Discovery and Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Haryana 125001, India |
| Abstract: | An easy, safe, solvent-free and effective method for the synthesis of pyrazole substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide (C-200) in high yield within short span of time. All reactions were carried out just by grinding the two reactants in the presence of activated barium hydroxide (C-200). Results are also compared with sodium hydroxide and potassium hydroxide. |
| Keywords: | Pyrazole aldehydes Chalcones Activated barium hydroxide (C-200) Solvent free conditions |
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