| 4-羟基香豆素及其衍生物的简便合成及其荧光性质的研究 |
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| 引用本文： | 高文涛,侯文端,郑美茹.4-羟基香豆素及其衍生物的简便合成及其荧光性质的研究[J].有机化学,2008,28(11):2011-2015. |
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| 作者姓名： | 高文涛 侯文端 郑美茹 |
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| 作者单位： | 渤海大学超精细化学品研究所,辽宁省应用化学重点试验室,锦州,121000 |
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| 摘 要： | 用米氏酸和苯酚在无溶剂条件下以90.6%的收率合成丙二酸单苯基酯, 然后用Eaton试剂(五氧化二磷＋甲基磺酸)在温和条件下闭环, 以78.8%的收率得到4-羟基香豆素, 将这种方法扩展合成了苯环上带有各种取代基的4-羟基香豆素衍生物以及4-羟基硫代香豆素衍生物. 并对部分4-羟基香豆素衍生物的荧光性质进行了研究.
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| 关 键 词： | 米氏酸 4-羟基香豆素 4-羟基硫代香豆素 Eaton试剂 多聚磷酸 |
| 收稿时间： | 2008-5-10 |
| 修稿时间： | 2008-7-13 |
Facile Preparation and Fluorescent Properties of 4-Hydroxycoumarin and Its Derivatives |
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| GAO,Wen-Tao,HOU,Wen-Duan,ZHENG,Mei-Ru.Facile Preparation and Fluorescent Properties of 4-Hydroxycoumarin and Its Derivatives[J].Chinese Journal of Organic Chemistry,2008,28(11):2011-2015. |
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| Authors: | GAO Wen-Tao HOU Wen-Duan ZHENG Mei-Ru |
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| Institution: | (Liaoning Key Laboratory of Applied Chemistry, Institute of Superfine Chemicals, Bohai University, Jinzhou 121000) |
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| Abstract: | The malonic acid mono phenol ester was synthesized by Meldrum’s acid and phenol under a solvent-free condition in 90.6% yield, then cyclized by Eaton’s reagent (phosphoric anhydride and methylsulfonic acid) in mild conditions to give 4-hydroxycoumarin in 78.8% yield. This methodology was then extended to prepare 4-hydroxycoumarin and 4-hydroxythiocoumarin derivatives. The fluorescent properties of some 4-hydroxycoumarin derivatives were studied. |
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| Keywords: | Meldrum’s acid 4-hydroxycoumarin 4-hydroxythiocoumarin Eaton’s reagent PPA |
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