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Solid-state of pharmaceutical compounds |
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| Authors: | Giron D. Mutz M. Garnier S. |
| Affiliation: | (1) Chemical and Analytical Research and Development, Novartis Pharma Group leader CHAD-ARD, Technical R&D, CH-4002 Basel, Switzerland;(2) Chemical and Analytical Research and Development, Novartis Pharma, CH-4002 Basel, Switzerland |
| Abstract: | This article summarizes the different steps needed for a proper design and monitoring of the solid-state in pharmaceutical industry in order to fulfill the requirements of the guideline dealing with polymorphism of the International Conference of Harmonization. This revised version was published online in July 2006 with corrections to the Cover Date. |
| Keywords: | kinetics polymorphism solvates monitoring hydrates amorphous forms design of the solid-state pharmaceuticals physical analytical methods quantification solid-state properties solid-state transformations thermodynamic relationships |
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