Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids |
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Authors: | Pellicciari Roberto Marinozzi Maura Camaioni Emidio del Carmen Nùnez Maria Costantino Gabriele Gasparini Fabrizio Giorgi Gianluca Macchiarulo Antonio Subramanian Natarajan |
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Institution: | Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo, 1, 06123 Perugia Italy. rp@unipg.it |
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Abstract: | In search for novel conformationally constrained analogues of L-glutamic acid, a diastereodivergent synthesis of the four 1-aminospiro2.2]pentyl-1,4-dicarboxylic acid racemic pairs is reported along with their stereochemical assignment, conformational analysis, and preliminary biological evaluation as potential glutamate (ionotropic and metabotropic) ligands. |
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