Thermoanalytical study of nimesulide and their recrystallization products obtained from solutions of several alcohols |
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Authors: | D A Gálico G L Perpétuo R A E Castro O Treu-Filho A O Legendre M S Galhiane G Bannach |
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Institution: | 1. Departamento de Química, Faculdade de Ciências, UNESP—Univ Estadual Paulista, S?o Paulo, CEP 17033-260, Brazil 2. Faculdade de Farmácia, CEF, Universidade de Coimbra, CEP 3000-548, Coimbra, Portugal 3. Instituto de Química, UNESP—Univ Estadual Paulista, S?o Paulo, CEP 14800-900, Brazil
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Abstract: | Thermogravimetry, differential scanning calorimetry, and vibrational infrared spectroscopy were used to study nimesulide and its recrystallization products that were obtained from solutions of several alcohols. The thermoanalytical measurements were performed in both air and nitrogen atmospheres and the results suggest that, under the experimental conditions used in this paper, it was possible to obtain neither polymorphic nor pseudopolymorphic forms of this drug. In this investigation, quantum chemical approach methods were used to determine the molecular structures using the Becke three-parameter hybrid method and the Lee–Yang–Parr correlation functional. The performed molecular calculations were done with the Gaussian 09 routine and the theoretical calculation results were correlated with the experimental IR vibrational spectrum. |
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