Small angle neutron scattering studies on the interaction of cationic surfactants with bovine serum albumin |
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Authors: | Nuzhat Gull S Chodankar V K Aswal Kabir-Ud-Din |
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Institution: | (1) Department of Chemistry, Aligarh Muslim University, Aligarh, 202 002, India;(2) Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai, 400 085, India |
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Abstract: | The structure of the protein-surfactant complex of bovine serum albumin (BSA) and cationic surfactants has been studied by
small angle neutron scattering. At low concentrations, the CTAB monomers are observed to bind to the protein leading to an
increase in its size. On the other hand at high concentrations, surfactant molecules aggregate along the unfolded polypeptide
chain of the protein resulting in the formation of a fractal structure representing a necklace model of micelle-like clusters
randomly distributed along the polypeptide chain. The fractal dimension as well as the size and number of micelles attached
to the complex have been determined.
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Keywords: | Small angle neutron scattering protein solution cationic surfactants |
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