| 双重作用机制卟啉靶向给药体系的研究进展 |
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| 引用本文： | 惠扬,马静,陶敏莉,周雪琴,刘东志.双重作用机制卟啉靶向给药体系的研究进展[J].化学通报,2007,70(11):812-822. |
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| 作者姓名： | 惠扬 马静 陶敏莉 周雪琴 刘东志 |
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| 作者单位： | 天津大学化工学院 天津300072 |
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| 摘 要： | 近年来卟啉化学研究的一个新热点是,依据卟啉类化合物在肿瘤细胞优先集聚的特点,将其作为携带剂介导现有抗癌药物,实现靶向给药,同时利用卟啉的光敏性,实现分子内加和增效,合成具有化学杀伤和光动力杀伤双重活性的卟啉-抗癌药物体系。本文主要就双重作用机制卟啉靶向给药体系的研究进展进行综述。
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| 关 键 词： | 卟啉 靶向给药 化学杀伤 光动力杀伤 抗癌药物 |
| 修稿时间： | 2007-02-02 |
Progress in Porphyrins as Targeting Drug Delivery Systems for Cancer Therapy |
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| Hui Yang,Ma Jing,Tao Minli,Zhou Xueqin,Liu Dongzhi.Progress in Porphyrins as Targeting Drug Delivery Systems for Cancer Therapy[J].Chemistry,2007,70(11):812-822. |
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| Authors: | Hui Yang Ma Jing Tao Minli Zhou Xueqin Liu Dongzhi |
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| Institution: | Department of Chemical Engineering, Tianjin University, Tianjin 300072 |
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| Abstract: | Porphyrins have recently emerged as a novel promising colloidal carrier system for the tumor-targeted drugs.They demonstrate impressing advantages not only as drug carrier but also they are photosensitive and play an important role in photodynamic therapy(PDT).To utilize the two advantages completely,porphyrin-anticarcinogen systems shown great chemical therapy and photodynamic therapy have been set up.The progress of porphyrin-anticarcinogen systems are reviewed in this paper. |
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| Keywords: | Porphyrin Targeting drug delivery system Chemical therapy Photodynamic therapy Anticarcinogen |
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