(Z)-tamoxifen and tetrasubstituted alkenes and dienes via a regio- and stereospecific three-component magnesium carbometalation palladium(0) cross-coupling strategy |
| |
| Authors: | Tessier Pierre E Penwell Andrea J Souza Fabio E S Fallis Alex G |
| |
| Institution: | Centre for Research in Biopharmaceuticals, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5. |
| |
| Abstract: | reaction: see text] The synthesis of various tetrasubstituted alkenes and dienes in a regio- and stereocontrolled manner is described. This three-component coupling strategy involves the addition of Grignard reagents to propargyl alcohols followed by palladium(0)-mediated cross-coupling with aryl or vinyl halides. This protocol has been applied to the synthesis of (Z)-Tamoxifen and related mimics. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
