First examples of improved catalytic asymmetric C-C bond formation using the monodentate ligand combination approach |
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Authors: | Duursma Ate Hoen Rob Schuppan Julia Hulst Ron Minnaard Adriaan J Feringa Ben L |
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Institution: | Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands. |
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Abstract: | reaction: see text] Using a combination of chiral monodentate phosphoramidite ligands in the rhodium-catalyzed conjugate addition of boronic acids to three different substrates, we have shown for the first time that the ligand combination approach is applicable for C-C bond formation. Chiral catalysts based on hetero-combinations of ligands are found to be more effective than the homo-combinations. (31)P NMR experiments show that the hetero-combinations are formed in excess over the homo-combinations. |
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