Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network |
| |
| Authors: | Shady Farah Oren Aviv Natalia Laout Stanislav Ratner Nurit Beyth Abraham J Domb |
| |
| Institution: | 1. Institute of Drug Research, School of Pharmacy—Faculty of Medicine, Center for Nanoscience and Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, , 91120 Israel;2. Strauss‐Water Co., , Petach Tikva, Israel;3. Department of Prosthodontics, Faculty of Dentistry, The Hebrew University‐Hadassah Jerusalem, , 91120 Israel |
| |
| Abstract: | Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S‐QA‐PEI). The synthesized S‐QA‐PEI particles were identified with a slight particle size increase of 2–3 µm. Different ratios of PEI:silica particles were prepared and analyzed. While silica particles are negatively charged, ?16.7 ± 5.11 mV, the prepared S‐QA‐PEI particles are positively charged, +50–60 mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity. Copyright © 2014 John Wiley & Sons, Ltd. |
| |
| Keywords: | polyethylenimine (PEI) silica particles interpenetrating polymer network antimicrobial surface |
|
|
