Effect of the manufacturing parameters on the structure of nitrogen-doped carbon nanotubes produced by catalytic laser-induced chemical vapor deposition |
| |
Authors: | Morjan Iuliana P Alexandrescu Rodica Morjan Ion Luculescu Catalin Vasile Eugeniu Osiceanu Petre Scarisoreanu Monica Demian Gabriela |
| |
Institution: | 1. College of Chemistry and Chemical Engineering, Henan Normal University; Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, 46# East of Construction Road, Xinxiang, 453007, People’s Republic of China
|
| |
Abstract: | Series of self-assembled and mono-dispersed bovine serum albumin (BSA)-conjugated ZnS/CuS nano-composites with different Zn/Cu ratios had been successfully synthesized by a combination method of the biomimetic synthesis and ion-exchange strategy under the gentle conditions. High-resolution transmission electron microscopy observation, Fourier transform infrared spectra and zeta potential analysis demonstrated that BSA-conjugated ZnS/CuS nano-composites with well dispersity had the hierarchical structure and BSA was a key factor to control the morphology and surface electro-negativity of final products. The real-time monitoring by atomic absorption spectroscopy and powder X-ray diffraction revealed that the Zn/Cu ratio of nano-composites could be controlled by adjusting the ion-exchange time. In addition, the metabolic and morphological assays indicated that the metabolic proliferation and spread of rat pheochromocytoma (PC12) cells could be inhibited by nano-composites, with the high anti-cancer activity at a low concentration (4 ppm). What were more important, Zn and Cu in nano-composites exhibited a positive cooperativity at inhibiting cancer cell functions. The microscope observation and biochemical marker analysis clearly revealed that the nano-composites-included lipid peroxidation and disintegration of membrane led to the death of PC12 cells. Summarily, the present study substantiated the potential of BSA-conjugated ZnS/CuS nano-composites as anti-cancer drug. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|