An Efficient Palladium and Bis(2‐pyridylmethyl)amine‐based System for Suzuki‐Miyaura Cross‐Coupling under Aqueous and Aerobic Condition |
| |
| Authors: | Jianjun Yu Limin Wang Mingtao Liu Jun Qiu Qiang Shen Lei Fang Jun Tang |
| |
| Affiliation: | Shanghai Key Laboratory of Functional Materials Chemistry and Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China |
| |
| Abstract: | A novel PdCl2/bis(2‐pyridylmethyl)amine‐based ligand ( 1 ) catalytic system, which is water‐soluble and air‐stable, has been successfully synthesized and applied for Suzuki‐Miyaura cross‐coupling reaction. In the presence of catalytic amount of PdCl2/ 1 system, arylboronic acids can couple with a wide range of aryl halides, including aryl bromides and aryl chlorides. The reactions proceed under mild conditions to give excellent yields, and a wide range of functionalities is tolerated. |
| |
| Keywords: | Suzuki‐Miyaura cross‐coupling bis(2‐pyridylmethyl)amine‐based ligand arylboronic acids aryl halides |
|
|
