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Efficient Synthesis of β‐Acetamido Ketones and Esters Using Aluminum Chloride as an Inexpensive and Green Catalyst |
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| Authors: | Zolfigol Mohammad Ali Khazaei Ardeshir Mokhlesi Mohammad Zare Abdolkarim Safaiee Maliheh Derakhshan‐Panah Fatemeh Keypour Hassan Ali Dehghani‐Firouzabadi Ahmad Merajoddin Maria |
| Institution: | 1. Faculty of Chemistry, Bu‐Ali Sina University, Hamedan, 6517838683, Iran;2. Department of Chemistry, Payame Noor University, PO BOX 19395‐3697 Tehran, Iran;3. College of Science, Islamic Azad University, Hamedan Branch, Iran |
| Abstract: | Aluminum chloride (AlCl3) efficiently catalyzes one‐pot multicomponent condensation of enolizable ketones or alkyl acetoacetates with aldehydes, acetonitrile and acetyl chloride to afford β‐acetamido ketone or ester derivatives in high to excellent yields and in relatively short reaction times. Moreover, by this synthetic method, some novel β‐acetamido ketones and esters (i.e. one complex structure) are prepared. |
| Keywords: | β ‐acetamido ketone β ‐acetamido ester aluminum chloride enolizable ketone synthetic methods multicomponent reactions |